In close cooperation with global market leaders for feed- and food-supplements we construct new microbial production strains for amino acids and bring world’s best production strains to even higher performance. Our nearly unlimited screening-throughput makes it possible to screen millions of genetic variants in minutes and to directly isolate the very best ones on the single-cell level. This enables analysis of full biological diversity after undirected mutagenesis, natural evolution approaches, identification of novel mutations for enhanced productivity and generation of a strong IP-position.
We apply the SenseUp-Technology to construct microbial strains for fermentative production of peptides used in adhesives, as feed-supplements, in nutrition-products or in other high-volume applications. Using well-established microorganisms like Corynebacterium glutamicum and our unique possibilities to tailor a perfect strain for each individual peptide, we enable production of bulk-peptides at low-cost and literally unlimited process scalability.
We use the SenseUp-Technology to optimize expression and secretion of pharmaceutical proteins in Gram-positive bacteria, especially Corynebacterium glutamicum. The SenseUp-Technology enables screening of billions of strains for each individual protein, analysis of combinatorial effects of secretion-signal sequence, codon usage, promoter strength, genomic background, etc. in parallel. This results in specifically optimized Corynebacterium strains for each individual protein, offering high protein secretion capacity (high yield), small amounts of endogenous extracellular proteins (high purity) and GRAS status (high safety).